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1850-1900
The
first form of the disorder was identified in adults. Toward the end of the century, the disease is described in
children.
1995 Two
research teams with MDA support announced that they had found the
“SMA gene” on Chromosome 5.
1996
Discovery
of SMA protein and development of carrier testing developed at Ohio
State University. A SMA
mouse model is created by Dr. Louis Sunard at the University of
Montreal.
1998
MDA
supports a trial of Gabapentin in the Chromosome 5 form of SMA.
Feb.
1, 2000
Dr.
Burghes, Ohio State University, finds a possible drug compound that
may be used to treat SMA. Scientists
begin to make plans for a human trial.
Aug.
2000
Scientists
at University of Bonn announced they had discovered how to stimulate
production of the missing SMA protein in animals with the disease.
April
2001 Dr.
Burghes identifies several compounds that may have an effect in cellular
models of SMA.
Nov.
2001
MDA
researchers continue to identify compounds that may have an effect in
cellular models of SMA.
Mar.
2002
Dr.
Brian Pollok, a researcher at Aurora Bioscience, discovers 5 to 6 drug
compounds
that positively modify the SMN protein.
Nov.
2002
Dr.
Christine D. Donato conducted research that demonstrates that gene
therapy shows strong potential as a cure or treatment for SMA.
June
2003
The
researchers identify Valproic Acid, a well-known drug, for potential use
in clinical trials in SMA children.
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